Toward precision medicine of breast cancer
Open Access
- 29 February 2016
- journal article
- review article
- Published by Springer Science and Business Media LLC in Theoretical Biology and Medical Modelling
- Vol. 13 (1), 1-46
- https://doi.org/10.1186/s12976-016-0035-4
Abstract
In this review, we report on breast cancer’s molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of developing precision medicine methods. We first address the current state of the art in breast cancer therapies and challenges in order to progress towards its cure. Then, we show how the interaction of high-throughput technologies with in silico modeling has led to set up useful inferences for promising strategies of target-specific therapies with low secondary effect incidence for patients. Finally, we discuss the challenge of pharmacogenetics in the clinical practice of cancer therapy. All these issues are explored within the context of precision medicine.Keywords
Funding Information
- Special issue of TBioMed on "Biophysical Models of Cell Behavior".
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