Admixture Mapping Comes of Age
Open Access
- 1 September 2010
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genomics and Human Genetics
- Vol. 11 (1), 65-89
- https://doi.org/10.1146/annurev-genom-082509-141523
Abstract
Admixture mapping is based on the hypothesis that differences in disease rates between populations are due in part to frequency differences in disease-causing genetic variants. In admixed populations, these genetic variants occur more often on chromosome segments inherited from the ancestral population with the higher disease variant frequency. A genome scan for disease association requires only enough markers to identify the ancestral chromosome segments; for recently admixed populations, such as African Americans, 1,500–2,500 ancestry-informative markers (AIMs) are sufficient. The method was proposed over 50 years ago, but the AIM panels and statistical methods required have only recently become available. Since the first admixture scan in 2005, the genetic bases for a range of diseases/traits have been identified by admixture mapping. Here, we provide a historical perspective, review AIM panels and software packages, and discuss recent successes and unexpected insights into human diseases that exhibit disparate rates across human populations.Keywords
This publication has 77 references indexed in Scilit:
- Finding the missing heritability of complex diseasesNature, 2009
- Results from a prostate cancer admixture mapping study in African-American menHuman Genetics, 2009
- Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetesDiabetologia, 2009
- A Genome-wide Analysis of Admixture in Uyghurs and a High-Density Admixture Map for Disease-Gene DiscoveryAmerican Journal of Human Genetics, 2008
- Analysis of Genomic Admixture in Uyghur and Its Implication in Mapping StrategyAmerican Journal of Human Genetics, 2008
- Estimating Local Ancestry in Admixed PopulationsAmerican Journal of Human Genetics, 2008
- Admixture Mapping of White Cell Count: Genetic Locus Responsible for Lower White Blood Cell Count in the Health ABC and Jackson Heart StudiesAmerican Journal of Human Genetics, 2008
- A second generation human haplotype map of over 3.1 million SNPsNature, 2007
- A worldwide survey of haplotype variation and linkage disequilibrium in the human genomeNature Genetics, 2006
- A haplotype map of the human genomeNature, 2005