The role of mobility and health disparities on the transmission dynamics of Tuberculosis
Open Access
- 28 January 2017
- journal article
- Published by Springer Science and Business Media LLC in Theoretical Biology and Medical Modelling
- Vol. 14 (1), 3
- https://doi.org/10.1186/s12976-017-0049-6
Abstract
The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfection and first time infection rates within high-incidence settings may influence the impact of control programs on TB prevalence. The impact that effective population size and the distribution of individuals’ residence times in different patches have on TB transmission and control are studied using selected scenarios where risk is defined by the estimated or perceive first time infection and/or exogenous re-infection rates. This study aims at enhancing the understanding of TB dynamics, within simplified, two patch, risk-defined environments, in the presence of short term mobility and variations in reinfection and infection rates via a mathematical model. The modeling framework captures the role of individuals’ ‘daily’ dynamics within and between places of residency, work or business via the average proportion of time spent in residence and as visitors to TB-risk environments (patches). As a result, the effective population size of Patch i (home of i-residents) at time t must account for visitors and residents of Patch i, at time t. The study identifies critical social behaviors mechanisms that can facilitate or eliminate TB infection in vulnerable populations. The results suggest that short-term mobility between heterogeneous patches contributes to significant overall increases in TB prevalence when risk is considered only in terms of direct new infection transmission, compared to the effect of exogenous reinfection. Although, the role of exogenous reinfection increases the risk that come from large movement of individuals, due to catastrophes or conflict, to TB-free areas. The study highlights that allowing infected individuals to move from high to low TB prevalence areas (for example via the sharing of treatment and isolation facilities) may lead to a reduction in the total TB prevalence in the overall population. The higher the population size heterogeneity between distinct risk patches, the larger the benefit (low overall prevalence) under the same “traveling” patterns. Policies need to account for population specific factors (such as risks that are inherent with high levels of migration, local and regional mobility patterns, and first time infection rates) in order to be long lasting, effective and results in low number of drug resistant cases.This publication has 49 references indexed in Scilit:
- Tuberculosis Recurrence after Completion Treatment in a European City: Reinfection or Relapse?PLOS ONE, 2013
- Modeling the Role of Public Transportation in Sustaining Tuberculosis Transmission in South AfricaAmerican Journal of Epidemiology, 2013
- Heterogeneity in tuberculosis transmission and the role of geographic hotspots in propagating epidemicsProceedings of the National Academy of Sciences of the United States of America, 2012
- Epidemiological models of Mycobacterium tuberculosis complex infectionsMathematical Biosciences, 2012
- How host heterogeneity governs tuberculosis reinfection?Proceedings. Biological sciences, 2012
- TuberculosisThe Lancet, 2011
- Types of drinkers and drinking settings: an application of a mathematical modelAddiction, 2010
- Knowledge and perception of pulmonary tuberculosis in pastoral communities in the middle and Lower Awash Valley of Afar region, EthiopiaBMC Public Health, 2010
- The impact of relative residence times on the distribution of heavy drinkers in highly distinct environmentsSocio-Economic Planning Sciences, 2010
- Exogenous re-infection and the dynamics of tuberculosis epidemics: local effects in a network model of transmissionJournal of The Royal Society Interface, 2006