Long-term estrogen deficiency lowers regional blood flow, resting systolic blood pressure, and heart rate in exercising premenopausal women
- 1 May 2007
- journal article
- Published by American Physiological Society in American Journal of Physiology-Endocrinology and Metabolism
- Vol. 292 (5), E1401-E1409
- https://doi.org/10.1152/ajpendo.00547.2006
Abstract
The cardiovascular consequences of hypoestrogenism in premenopausal women are unclear. Accordingly, the influence of menstrual status and endogenous estrogen (E2) exposure on blood pressure (BP), heart rate (HR), and calf blood flow in young (18–35 yr) regularly exercising premenopausal women with exercise-associated menstrual aberrations was investigated. Across consecutive menstrual cycles, daily urinary ovarian steroid levels were analyzed, and the area under the curve was calculated to determine menstrual status and E2exposure. BP, HR, blood flow, vascular conductance, and resistance were measured at baseline and following ischemic calf exercise. Exercising subjects consisted of 14 ovulatory (ExOv), 10 short-term (anovulatory and ≤100 days amenorrhea; ST-E2Def), and 8 long-term (>100 days amenorrhea; LT-E2Def) E2-deficient women. Nine sedentary ovulatory subjects (SedOv) were also studied. All groups were similar in age (24.8 ± 0.7 yr), height (164.8 ± 1.3 cm), weight (57.9 ± 0.9 kg), and body mass index (21.3 ± 0.3 kg/m2). E2-deficient groups had lower ( P < 0.002) E2exposure compared with ovulatory groups. Resting systolic BP, HR, blood flow, and vascular conductance were lower ( P < 0.05) and vascular resistance higher ( P < 0.05) in LT-E2Def compared with both ovulatory groups. Peak ischemic blood flow, vascular conductance, and HR were also lower ( P < 0.05) and vascular resistance higher ( P < 0.05) in LT-E2Def compared with all other groups. Our findings show that exercising women with long-term E2deficiency have impaired regional blood flow and lower systolic BP and HR compared with exercising and sedentary ovulatory women. These cardiovascular alterations represent markers of altered vascular function and autonomic regulation of which the long-term effects remain unknown.Keywords
This publication has 41 references indexed in Scilit:
- Impaired Endothelium-Dependent and -Independent Vasodilation in Young Female Athletes With Exercise-Associated AmenorrheaArteriosclerosis, Thrombosis, and Vascular Biology, 2006
- Medical complications in adolescents with anorexia nervosa: A review of the literatureInternational Journal of Eating Disorders, 2005
- Physiological aspects and clinical sequelae of energy deficiency and hypoestrogenism in exercising womenHuman Reproduction Update, 2004
- Effects of transdermal estrogens on endothelial function in postmenopausal women with coronary diseaseClimacteric, 2003
- Estrogen upregulates nitric oxide synthase expression in cultured rat hepatic sinusoidal endothelial cellsJournal of Hepatology, 2001
- Methoxyestradiols Mediate the Antimitogenic Effects of Estradiol on Vascular Smooth Muscle Cells via Estrogen Receptor-Independent MechanismsBiochemical and Biophysical Research Communications, 2000
- High Frequency of Luteal Phase Deficiency and Anovulation in Recreational Women Runners: Blunted Elevation in Follicle-Stimulating Hormone Observed during Luteal-Follicular TransitionJournal of Clinical Endocrinology & Metabolism, 1998
- Menopause and the Risk of Coronary Heart Disease in WomenThe New England Journal of Medicine, 1987
- Fasting, Feeding and Regulation of the Sympathetic Nervous SystemThe New England Journal of Medicine, 1978
- LIMB CIRCULATION IN ANOREXIA NERVOSAActa Paediatrica, 1978