Major impact of admission glycaemia on 30 day and one year mortality in non-diabetic patients admitted for myocardial infarction: results from the nationwide French USIC 2000 study
Open Access
- 2 May 2006
- Vol. 92 (7), 910-915
- https://doi.org/10.1136/hrt.2005.073791
Abstract
To analyse the short and long term prognostic significance of admission glycaemia in a large registry of non-diabetic patients with acute myocardial infarction.Assessment of short and long term prognostic significance of admission blood glucose in a consecutive population of 1604 non-diabetic patients admitted to intensive care units in France in November 2000 for a recent (<or= 48 hours) myocardial infarction.In-hospital mortality, compared with that of patients with admission glycaemia below the median value of 6.88 mmol/l (3.7%), rose gradually with each of the three upper sextiles of glycaemia: 6.5%, 12.5% and 15.2%. Conversely, one year survival decreased from 92.5% to 88%, 83% and 75% (p < 0.001). Admission glycaemia remained an independent predictor of in-hospital and one year mortality after multivariate analyses accounting for potential confounders. Increased admission glycaemia also was a predictor of poor outcome in all clinical subsets studied: patients without heart failure on admission, younger and older patients, patients with or without reperfusion therapy, and patients with or without ST segment elevation.In non-diabetic patients, raised admission blood glucose is a strong and independent predictor of both in-hospital and long term mortality.Keywords
This publication has 25 references indexed in Scilit:
- Impact of Prehospital Thrombolysis for Acute Myocardial Infarction on 1-Year OutcomeCirculation, 2004
- Admission Blood Glucose Level as Risk Indicator of Death After Myocardial Infarction in Patients With and Without Diabetes MellitusArchives of Internal Medicine, 2004
- Acute hyperglycemia abolishes ischemic preconditioning in vivo.American Journal of Physiology-Heart and Circulatory Physiology, 1998
- Management of Acute Myocardial Infarction in Intensive Care Units in 1995: A Nationwide French Survey of Practice and Early Hospital ResultsJournal of the American College of Cardiology, 1997
- The Prognostic Value of Blood Glucose in Diabetic Patients with Acute Myocardial InfarctionDiabetic Medicine, 1996
- Thromboxane Biosynthesis and Platelet Function in Type II Diabetes MellitusNew England Journal of Medicine, 1990
- Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic ComplicationsNew England Journal of Medicine, 1988
- Myocardial infarction in patients with diabetes mellitusEuropean Heart Journal, 1988
- Determinants and importance of stress hyperglycaemia in non-diabetic patients with myocardial infarction.BMJ, 1986
- Serial plasma catecholamine response early in the course of clinical acute myocardial infarction: Relationship to infarct extent and mortalityAmerican Heart Journal, 1981