Effects of eight weeks' continuous treatment with oral ranitidine and cimetidine on gastric acid secretion, pepsin secretion, and fasting serum gastrin.
Open Access
- 1 January 1983
- Vol. 24 (1), 61-66
- https://doi.org/10.1136/gut.24.1.61
Abstract
Gastric acid secretion, pepsin secretion, and fasting serum gastrin levels were measured in 23 patients with duodenal ulcer disease, divided into three groups which received either cimetidine 800 mg daily, cimetidine 1600 mg daily, or ranitidine hydrochloride 300 mg daily for eight weeks. Pentagastrin tests were carried out at intervals both before and after treatment. Each dose of cimetidine reduced acid secretion to 42% of control one week after starting therapy. Ranitidine reduced acid secretion to 33% of the pretreatment value. Acid secretion remained suppressed to these levels throughout treatment with each drug. Acid secretion returned to pretreatment levels in all patients one week after treatment and remained normal until the end of the study. Both drugs reduced pepsin, which fell to 64% and 61% (p less than 0.01) after 800 mg and 1600 mg cimetidine respectively and to 65% (p less than 0.005) with ranitidine after one week's treatment. Pepsin secretion remained at this reduced level in both cimetidine groups till the end of treatment. Pepsin levels fell to 50% at two weeks of therapy with ranitidine but stabilised at this level till the end of therapy. Cimetidine withdrawal was followed by a return towards pretreatment levels of pepsin secretion; but secretion remained significantly depressed (p less than 0.05) to the end of the study period. In the ranitidine-treated patients pepsin output returned to normal after drug withdrawal. Fasting gastrin levels rose during treatment with both drugs but failed to reach significant levels. After withdrawal of treatment fasting serum gastrin levels returned to normal in all three groups of patients.Keywords
This publication has 16 references indexed in Scilit:
- Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients.Gut, 1980
- Ranitidine--a new H2-receptor antagonist.Gut, 1980
- Untersuchung über die Wirkungsdauer von RanitidinDeutsche Medizinische Wochenschrift (1946), 1980
- PHARMACOLOGICALLY EFFECTIVE PLASMA CONCENTRATIONS OF RANITIDINEThe Lancet, 1979
- INHIBITION OF PENTAGASTRIN-STIMULATED AND NOCTURNAL GASTRIC SECRETION BY RANITIDINE: A New H2-receptor AntagonistThe Lancet, 1979
- Effect of cimetidine on 24-hour intragastric acidity in normal subjects.Gut, 1976
- 24-HOUR CONTROL OF INTRAGASTRIC ACIDITY BY CIMETIDINE IN DUODENAL-ULCER PATIENTSThe Lancet, 1975
- GASTRIC-ACID OUTPUT, PEPSIN OUTPUT, AND LEAN BODY MASS IN NORMAL AND DUODENAL-ULCER SUBJECTSThe Lancet, 1975
- The effect of histamine H2-receptor blockade with metiamide on serum gastrin levels in man.Gut, 1975
- Effect of Large Doses of Histamine on Gastric Secretion of HClBMJ, 1953