Epidemiology of paediatric invasive fungal infections and a case‐control study of risk factors in acute leukaemia or post stem cell transplant
- 22 March 2010
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 149 (2), 263-272
- https://doi.org/10.1111/j.1365-2141.2009.08072.x
Abstract
P>Patients aged 0-18 years with confirmed or possible invasive fungal infection were identified by medical record and database searches. Cases with an underlying diagnosis of acute leukaemia or following stem cell transplantation were included in a case control study. Controls included all other children with acute leukaemia or stem cell transplant in the corresponding time period. Variables collected included demographics, underlying disease risk and status, organ impairment, admission to intensive care unit, fungal infection details and certain transplant variables. Risk factors for development of invasive fungal infection were examined using logistic regression. There were 106 cases of invasive fungal infection during the study. The incidence of invasive fungal infection was 21% in acute lymphoblastic leukaemia, 15% in acute myeloid leukaemia and 25% following stem cell transplantation. Sixty per cent were neutropenic at diagnosis and 39% had concomitant bacteremia. High risk acute lymphoblastic leukaemia, relapsed disease, intensive care admission and graft-versus-host disease were significantly associated with development of invasive fungal infection on multivariate analysis. These associations provide new information on paediatric invasive fungal infections and warrant further study; caution should be encouraged when extrapolating from adult studies.Keywords
This publication has 42 references indexed in Scilit:
- Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered AgentsClinical Infectious Diseases, 2009
- Active Surveillance of Candidemia, AustraliaEmerging Infectious Diseases, 2006
- Fungal Infections in Children With CancerThe Pediatric Infectious Disease Journal, 2006
- Frequency of Fungemia in Hospitalized Pediatric Inpatients Over 11 Years at a Tertiary Care InstitutionPublished by American Academy of Pediatrics (AAP) ,2005
- Bloodstream infections and invasive mycoses in children undergoing acute leukaemia treatment: A 13-year experience at a single Italian institutionEuropean Journal Of Cancer, 2005
- Epidemiology and Predictors of Mortality in Cases of Candida Bloodstream Infection: Results from Population-Based Surveillance, Barcelona, Spain, from 2002 to 2003Journal of Clinical Microbiology, 2005
- A prospective study on fungal infection in children with cancerJournal of Medical Microbiology, 2002
- Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International ConsensusClinical Infectious Diseases, 2002
- Aspergillosis in Children with Cancer: A 34-Year ExperienceClinical Infectious Diseases, 1999
- Deep Infections Caused by Scedosporium prolificans: A Report on 16 Cases in Spain and a Review of the LiteratureMedicine, 1997