Evaluation of a New Hemostatic Agent Ankaferd Blood Stopper in Experimental Liver Laceration
- 1 January 2009
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Investigative Surgery
- Vol. 22 (3), 201-206
- https://doi.org/10.1080/08941930902866246
Abstract
Hemorrhage is a leading cause of death after trauma. It is also the major cause of operating room deaths among patients who undergo liver surgery. Various techniques and materials have been attempted to manage bleeding, but a standard method has not been defined yet. We studied the hemostatic effects of Ankaferd Blood Stopper on liver injury in comparison with regenerated oxidized cellulose. Thirty Wistar albino rats underwent partial hepatic laceration by scissors. The animals were randomized to the treatment of resected surface with either Ankaferd Blood Stopper (ABS, n = 11) or regenerated oxidized cellulose (Surgicel, n = 9), or were left untreated (controls, n = 10). All the animals were resuscitated with lactated Ringer's solution at 3.3 ml/min/kg to a mean arterial pressure (MAP) of 100 mmHg. Survival time, total blood loss, resuscitation volume, and MAP were recorded for 30 min or until death. The rats that were alive at the end of 30 min were sacrificed with blood withdrawal from catheters. Rats in the ABS and Surgicel groups survived significantly longer than rats in the control group (p =.0001). There were no significant differences between the ABS and the Surgicel groups in survival (p =.91). Application of ABS and Surgicel was associated with a significant reduction in blood loss compared to controls (p =.008), with no significant differences between active treatment groups (p =.74). The resuscitation volume was not different. ABS is as effective as Surgicel in achieving hemostasis following partial liver excision in an experimental rat model.Keywords
This publication has 22 references indexed in Scilit:
- Propagation of Blood Clotting in the Complex Biochemical Network of Hemostasis Is Described by a Simple MechanismJournal of the American Chemical Society, 2007
- Use of the Hemostatic Agent QuikClot® for the Treatment of Massive Splenic Injury in a Rat ModelEuropean Surgical Research, 2007
- Comparative evaluation of absorbable hemostats: advantages of fibrin-based sheetsBiomaterials, 2004
- The use of local agents: bone wax, gelatin, collagen, oxidized celluloseEuropean Spine Journal, 2004
- Haemostasis in spine surgery. The use of local agents: Surgicel and SurgifoamEuropean Spine Journal, 2004
- Advanced Hemostatic Dressing Development Program: Animal Model Selection Criteria and Results of a Study of Nine Hemostatic Dressings in a Model of Severe Large Venous Hemorrhage and Hepatic Injury in SwineThe Journal of Trauma and Acute Care Surgery, 2003
- Effect of a Chitosan-Based Hemostatic Dressing on Blood Loss and Survival in a Model of Severe Venous Hemorrhage and Hepatic Injury in SwineThe Journal of Trauma and Acute Care Surgery, 2003
- Early intensive care unit intervention for trauma care: what alters the outcome?Current Opinion in Critical Care, 2002
- DEATH IN THE OPERATING ROOMThe Journal of Trauma and Acute Care Surgery, 1994
- Packing and Planned Reexploration for Hepatic and Retroperitoneal Hemorrhage: Critical Refinements of a Useful TechniqueThe Journal of Trauma and Acute Care Surgery, 1990