A Randomized, Single‐Blind Study of Lansoprazole for the Prevention of Exacerbations of Chronic Obstructive Pulmonary Disease in Older Patients
- 29 July 2009
- journal article
- research article
- Published by Wiley in Journal of the American Geriatrics Society
- Vol. 57 (8), 1453-1457
- https://doi.org/10.1111/j.1532-5415.2009.02349.x
Abstract
To investigate whether proton pump inhibitor (PPI) therapy reduces the frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease (COPD). Twelve-month, randomized, observer-blind, controlled trial. A university hospital and three city hospitals in Miyagi prefecture in Japan. One hundred patients with COPD (mean age +/- SD 74.9 +/- 8.2) participated. They were all ex-smokers and had received conventional therapies for COPD, including smoking cessation and bronchodilators. Patients with gastroesophageal reflux disease or gastroduodenal ulcer were excluded. Patients were randomly assigned to conventional therapies (control group) or conventional therapies plus PPI (lansoprazole 15 mg/d; PPI group) and observed for 12 months. Frequency of common colds and COPD exacerbations. The number of exacerbations per person in a year in the PPI group was significantly lower than that in the control group (0.34 +/- 0.72 vs 1.18 +/- 1.40; P<.001). The adjusted odds ratio with logistic regression for having exacerbation (> or =once/year) in the PPI group compared with the control group was 0.23 (P=.004). In contrast, there was no significant difference in the numbers of common colds per person per year between the PPI group and the control group (1.22 +/- 2.09 vs 2.04 +/- 3.07; P=.12). PPI therapy significantly reduced the risk of catching frequent common colds (> or =3 times/year), the adjusted odds ratio of which was 0.28 (P=.048). In this single-blind, nonplacebo-controlled trial, lansoprazole was associated with a significant decrease in COPD exacerbations. More definitive clinical trials are warranted.Keywords
This publication has 17 references indexed in Scilit:
- Relationship Between Gastroesophageal Reflux Disease and COPD in UK Primary CareChest, 2008
- Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbationThorax, 2008
- Role of Gastroesophageal Reflux Symptoms in Exacerbations of COPDChest, 2006
- How Viral Infections Cause Exacerbation of Airway DiseasesChest, 2006
- CARBOCISTEINE REDUCES FREQUENCY OF COMMON COLDS AND EXACERBATIONS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASEJournal of the American Geriatrics Society, 2006
- The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cellsEuropean Journal of Pharmacology, 2005
- Recent clinical investigations examining the association of asthma and gastroesophageal refluxAmerican Journal Of Medicine, 2003
- Erythromycin and Common Cold in COPDChest, 2001
- The major human rhinovirus receptor is ICAM-1Cell, 1989
- Transmission of the Common Cold to Volunteers Under Controlled ConditionsA.M.A. Archives of Internal Medicine, 1958