In utero exposure to helminth and mycobacterial antigens generates cytokine responses similar to that observed in adults.
Open Access
- 1 April 1997
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 99 (7), 1759-1766
- https://doi.org/10.1172/jci119340
Abstract
Neonates exposed to parasite antigens (Ags) in utero may develop altered fetal immunity that could affect subsequent responses to infection. We hypothesized that cord blood lymphocytes (CBL) from offspring of mothers residing in an area highly endemic for schistosomiasis, filariasis, and tuberculosis in Kenya would either fail to respond or generate a predominantly Th2-associated cytokine response to helminth and mycobacterial antigens (PPD) in vitro compared to maternal PBMC. Kenyan CBL generated helminth Ag-specific IL-5 (range 29-194 pg/ml), IL-10 (121-2,115 pg/ml), and/or IFN-gamma (78 pg/ml-10.6 ng/ml) in 26, 46, and 57% of neonates, respectively (n = 40). PPD induced IFN-gamma in 30% of Kenyan CBL (range 79-1,896 pg/ml), but little or no IL-4 or IL-5. No Ag-specific IL-4, IL-5, or IFN-gamma release was detected by CBL obtained in the United States (n = 11). Ag-driven cytokine production was primarily CD4-dependent. Cytokine responses to helminth and mycobacterial Ags by maternal PBMC mirrored that observed in neonates. CBL from helminth infected and/or PPD-sensitized mothers produced more Ag-specific cytokines compared to CBL from uninfected mothers (P < 0.05). These data demonstrate that the human fetus develops similar patterns of cytokine production observed in adults and indicates that prenatal exposure may not lead to tolerance or altered fetal immunity. .Keywords
This publication has 49 references indexed in Scilit:
- Induction of T H 1 and T H 2 Immunity in Neonatal MiceScience, 1996
- Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic CellsScience, 1996
- CD28 activation promotes Th2 subset differentiation by human CD4+ cellsEuropean Journal of Immunology, 1995
- Regulation of the immune response in lymphatic filariasis and onchocerciasisImmunology Today, 1991
- Immunization of Pregnant Women with a Polysaccharide Vaccine of Group B StreptococcusNew England Journal of Medicine, 1988
- Transplacental immunization of the human fetus to tetanus by immunization of the mother.JCI Insight, 1983
- Prenatal allergic sensitization to helminth antigens in offspring of parasite-infected mothers.JCI Insight, 1983
- Antibody response to serogroup A and C meningococcal polysaccharide vaccines in infants born of mothers vaccinated during pregnancy.JCI Insight, 1980
- Induction of Immunological Hyporesponsiveness to Granulomatous Hypersensitivity in Schistosoma mansoni InfectionThe Journal of Infectious Diseases, 1974
- Passage of Leukocytes from Mother to FetusScandinavian Journal of Immunology, 1974