Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia
- 1 August 2006
- journal article
- research article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 100 (8), 791-794
- https://doi.org/10.1016/j.trstmh.2005.10.016
Abstract
Elevated intestinal permeability, measured as an increased lactulose:mannitol (L:M) ratio, indicates injury of the small intestinal mucosa. As part of a randomized iron and multi-micronutrient (without iron) supplementation trial (Nchito et al., 2004), we determined intestinal permeability in a subgroup of schoolchildren at 10 months' follow-up to assess the effect of the interventions. Among 153 children (mean age 10.2 years and 53.6% girls) iron supplementation resulted in a higher L:M ratio compared with placebo (0.29 vs. 0.21, P=0.025). There was no effect of multi-micronutrient supplementation, and no interaction between the interventions. The finding could be one of the mechanisms explaining the negative effects of medicinal iron supplementation on morbidity found in some other studies.Keywords
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