Role of oxidative stress, infection and inflammation in male infertility
Top Cited Papers
- 20 December 2018
- journal article
- review article
- Published by Hindawi Limited in Andrologia
- Vol. 50 (11), e13126
- https://doi.org/10.1111/and.13126
Abstract
Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, has been linked to sperm damage and male infertility. There are many sources of OS and inflammation including varicocele, tobacco usage, alcohol, obesity/metabolic syndrome, leukocytospermia, sexually transmitted disease (i.e., Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum), bacterial prostatitis, microorganism mutations leading to more OS, and viral infections (i.e., human immunodeficiency virus, hepatitis). This review is focusing on infection and inflammation‐mediated OS, the inflammatory markers underlying pathology, clinical significance in male infertility, and a brief description of the recommended treatment modalities.Keywords
This publication has 130 references indexed in Scilit:
- Immune Evasion and Recognition of the Syphilis Spirochete in Blood and Skin of Secondary Syphilis Patients: Two Immunologically Distinct CompartmentsPLoS Neglected Tropical Diseases, 2012
- Effects of Hepatitis B Virus S Protein Exposure on Sperm Membrane Integrity and FunctionsPLOS ONE, 2012
- The great debate: varicocele treatment and impact on fertilityFertility and Sterility, 2011
- Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice GuidelineJournal of Clinical Endocrinology & Metabolism, 2010
- Nitrite, NO and hypoxic vasodilationBritish Journal of Pharmacology, 2009
- Role of reactive oxygen species in antibiotic action and resistanceCurrent Opinion in Microbiology, 2009
- The presence of bacteria species in semen and sperm qualityJournal of Assisted Reproduction and Genetics, 2008
- Exploring the full spectrum of macrophage activationNature Reviews Immunology, 2008
- Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycyclineSexually Transmitted Infections, 2006
- Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 ActivationJournal of Virology, 2006