Membrane Traffic Within the Golgi Apparatus
- 1 November 2009
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 25 (1), 113-132
- https://doi.org/10.1146/annurev.cellbio.24.110707.175421
Abstract
Newly synthesized secretory cargo molecules pass through the Golgi apparatus while resident Golgi proteins remain in the organelle. However, the pathways of membrane traffic within the Golgi are still uncertain. Most of the available data can be accommodated by the cisternal maturation model, which postulates that Golgi cisternae form de novo, carry secretory cargoes forward and ultimately disappear. The entry face of the Golgi receives material that has been exported from transitional endoplasmic reticulum sites, and the exit face of the Golgi is intimately connected with endocytic compartments. These conserved features are enhanced by cell-type-specific elaborations such as tubular connections between mammalian Golgi cisternae. Key mechanistic questions remain about the formation and maturation of Golgi cisternae, the recycling of resident Golgi proteins, the origins of Golgi compartmental identity, the establishment of Golgi architecture, and the roles of Golgi structural elements in membrane traffic.Keywords
This publication has 133 references indexed in Scilit:
- Tracing the Retrograde Route in Protein TraffickingCell, 2008
- Role of the conserved oligomeric Golgi (COG) complex in protein glycosylationCarbohydrate Research, 2008
- Transport through the Golgi Apparatus by Rapid Partitioning within a Two-Phase Membrane SystemCell, 2008
- Golgi Localization of Glycosyltransferases Requires a Vps74p OligomerDevelopmental Cell, 2008
- Morphogenesis of post-Golgi transport carriersHistochemistry and Cell Biology, 2008
- Assembly, organization, and function of the COPII coatHistochemistry and Cell Biology, 2007
- Asymmetric CLASP-Dependent Nucleation of Noncentrosomal Microtubules at the trans-Golgi NetworkDevelopmental Cell, 2007
- The Debate about Transport in the Golgi—Two Sides of the Same Coin?Cell, 2000
- The Golgi complex: In vitro veritas?Cell, 1992
- A new type of coated vesicular carrier that appears not to contain clathrin: Its possible role in protein transport within the Golgi stackCell, 1986