Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces
- 3 October 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Antonie van Leeuwenhoek
- Vol. 91 (1), 1-17
- https://doi.org/10.1007/s10482-006-9095-5
Abstract
Gram-positive bacteria, notably Bacillus and Streptomyces, have been used extensively in industry. However, these microorganisms have not yet been exploited for the production of the biodegradable polymers, polyhydroxyalkanoates (PHAs). Although PHAs have many potential applications, the cost of production means that medical applications are currently the main area of use. Gram-negative bacteria, currently the only commercial source of PHAs, have lipopolysaccharides (LPS) which co-purify with the PHAs and cause immunogenic reactions. On the other hand, Gram- positive bacteria lack LPS, a positive feature which justifies intensive investigation into their production of PHAs. This review summarizes currently available knowledge on PHA production by Gram- positive bacteria especially Bacillus and Streptomyces. We hope that this will form the basis of further research into developing either or both as a source of PHAs for medical applications.Keywords
This publication has 84 references indexed in Scilit:
- Functional evidence for a supramolecular structure for the Streptomyces lividans potassium channel KcsABiochemical and Biophysical Research Communications, 2004
- Streptomyces lividans potassium channel KcsA is regulated by the potassium electrochemical gradientBiochemical and Biophysical Research Communications, 2004
- Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthaseNatural Product Reports, 2003
- Polyhydroxyalkanoate synthase from Bacillus sp. INT005 is composed of PhaC and PhaRJournal of Bioscience and Bioengineering, 2002
- PhaC and PhaR Are Required for Polyhydroxyalkanoic Acid Synthase Activity in Bacillus megateriumJournal of Bacteriology, 2001
- Biosynthesis of novel copolyesters containing 3-hydroxypivalic acid by Rhodococcus ruber NCIMB 40126 and related bacteriaFEMS Microbiology Letters, 1998
- Accumulation of intracellular carbon reserves in relation to chloramphenicol biosynthesis by Streptomyces venezuelaeCanadian Journal of Microbiology, 1993
- Morphology of poly-β-hydroxybutyrate granulesJournal of Molecular Biology, 1968
- Metabolism of poly(β-hydroxybutyrate). I. Purification, composition, and properties of native poly(β-hydroxybutyrate) granules from Bacillus megateriumBiochemistry, 1968
- Structure of Poly- -hydroxybutyric Acid GranulesJournal of General Microbiology, 1964