Oxidative Stress and Adult Neurogenesis
- 23 June 2015
- journal article
- review article
- Published by Springer Science and Business Media LLC in Stem Cell Reviews and Reports
- Vol. 11 (5), 706-709
- https://doi.org/10.1007/s12015-015-9603-y
Abstract
There is a growing evidence that adult neurogenesis is critical for brain function. The reactive oxygen species (ROS) is accumulated during adult neurogenesis as a physiological mechanism; while ROS overload impairs adult neurogenesis during ageing, neuroinflammation and neurodegeneration. Here we propose that targeting oxidative stress provides a novel way to regulate adult neurogenesis and manage different brain diseases.Keywords
This publication has 46 references indexed in Scilit:
- Roles of olfactory system dysfunction in depressionProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2014
- Evidence of adult neurogenesis in non-human primates and humanCell and tissue research, 2014
- Mitochondrial DNA Damage Level Determines Neural Stem Cell Differentiation FateJournal of Neuroscience, 2011
- Adult neurogenesis in the hypothalamus: evidence, functions, and implications.CNS & Neurological Disorders - Drug Targets, 2011
- Redox dysregulation, neurodevelopment, and schizophreniaCurrent Opinion in Neurobiology, 2009
- Neurogliogenesis in the mature olfactory system: A possible protective role against infection and toxic dustBrain Research Reviews, 2009
- Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseasesNeuroscience, 2008
- Redox regulation in disease and ageingCell Death & Differentiation, 2004
- Running enhances neurogenesis, learning, and long-term potentiation in miceProceedings of the National Academy of Sciences of the United States of America, 1999
- Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrusNature Neuroscience, 1999