Anti‐β2‐glycoprotein I antibodies
- 21 May 2013
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1285 (1), 44-58
- https://doi.org/10.1111/nyas.12080
Abstract
Anti-β(2)-glycoprotein I (anti-β(2)GPI) antibodies are the main antiphospholipid antibodies, along with anticardiolipin and lupus anticoagulant, that characterize the autoimmune disease antiphospholipid syndrome (APS). While the exact physiological functions of β(2)GPI are unknown, there is overwhelming evidence that anti-β(2)GPI antibodies are pathogenic, contributing to thrombosis, pregnancy morbidity, and accelerated atherosclerosis in APS and systemic lupus erythematosus patients. The revelation that these antibodies play a central role in the pathogenesis and pathophysiology of APS has driven research to characterize the physiology and structure of β(2)GPI as well as the pathogenic effects of anti-β(2)GPI antibodies. It has also resulted in the development of improved testing methodologies for detecting these antibodies. In this review we discuss the characteristics of β(2)GPI; the generation, pathogenic effects, and standardized testing of anti-β(2)GPI antibodies; and the potential use of therapies that target the β(2)GPI/anti-β(2)GPI interaction in the treatment of APS.Keywords
This publication has 98 references indexed in Scilit:
- Anti-phospholipid induced murine fetal loss: Novel protective effect of a peptide targeting the β2 glycoprotein I phospholipid-binding site. Implications for human fetal lossJournal of Autoimmunity, 2012
- A novel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodiesBlood, 2012
- β2-glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse modelBlood, 2011
- Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndromeBlood, 2011
- Toll-like receptor (TLR)-4 mediates anti-β2GPI/β2GPI-induced tissue factor expression in THP-1 cellsClinical and Experimental Immunology, 2010
- The dual role of innate immunity in the antiphospholipid syndromeLupus, 2010
- Impaired Fibrinolysis in the Antiphospholipid SyndromeCurrent Rheumatology Reports, 2010
- ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro‐Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 PathwayAmerican Journal of Reproductive Immunology, 2009
- Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studiesAnnals Of The Rheumatic Diseases, 2007
- Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human β2‐glycoprotein I: Mutation studies including residues R39 to R43Arthritis & Rheumatism, 2007