RIP1 comes back to life as a cell death regulator in TNFR1 signaling
Open Access
- 13 January 2011
- journal article
- Published by Wiley in The FEBS Journal
- Vol. 278 (6), 877-887
- https://doi.org/10.1111/j.1742-4658.2011.08016.x
Abstract
Cell death induction by tumor necrosis factor has been an intensively studied area for the last two decades. Although it may appear that the skeleton should have been picked clean by now, new secrets about tumor necrosis factor death signaling are still being uncovered. In particular, the recent evidence that ubiquitination of the death kinase receptor‐interacting protein 1 regulates its participation in apoptotic and necrotic cell death is opening up unexplored avenues in the catacombs of tumor necrosis factor death signaling. In this minireview, we focus on two major cell‐death checkpoints that determine whether receptor‐interacting protein 1 functions as a pro‐survival or pro‐death molecule.Keywords
This publication has 85 references indexed in Scilit:
- Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and RegulationMolecular Cell, 2010
- NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domainThe EMBO Journal, 2009
- Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced InflammationCell, 2009
- Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-αCell, 2009
- Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKɛ Promotes Cell TransformationMolecular Cell, 2009
- NEMO/IKKγ regulates an early NF-κB-independent cell-death checkpoint during TNF signalingCell Death & Differentiation, 2009
- Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death PathwayCell, 2008
- Ubiquitination of RIP1 Regulates an NF-κB-Independent Cell-Death Switch in TNF SignalingCurrent Biology, 2007
- Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMOMolecular Cell, 2006
- Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin ChainCell, 2000