Musculoskeletal manifestations in end-stage renal disease patients on hemodialysis and relation to parathyroid dysfunction
Open Access
- 1 January 2019
- journal article
- research article
- Published by Medknow in Saudi Journal of Kidney Diseases and Transplantation
- Vol. 30 (1), 68-82
- https://doi.org/10.4103/1319-2442.252935
Abstract
End-stage renal disease (ESRD) is associated with chronic kidney disease-mineral and bone disorder (CKD-MBD); including renal osteodystrophy, and biochemical changes reflecting mineral and hormonal abnormalities. CKD-MBD can lead to serious musculoskeletal manifestations with an impact on the functional status of patients. The objective is to find the frequency of the musculoskeletal manifestations in dialysis patients, to determine the impact on the functional ability of patients, and to detect the relation between parathyroid hormone (PTH) level and musculoskeletal manifestations. The sample size included 53 adult patients on hemodialysis (HD), three times weekly, divided into two groups as follows; (Group A) included 15 patients (10 males and 5 females) on HD for a year or 1 year. All patients were subjected to a full history and physical examination plus a comprehensive assessment of patient's disability was done with a health assessment questionnaire (HAQ)-disability index. The most common neurological manifestations are uremic polyneuropathy (43.4%) and carpal tunnel syndrome. Arthralgia is the most common musculoskeletal manifestation (83%).The most common radiological signs of SHPT is the subperiosteal resorption of the terminal phalanges (67.9%). The most common MSUS abnormalities are Achilles tendinopathy (67.9%). Osteoporosis is detected in 24.5% of patient. There are highly positive significant correlations between HAQ score and age, HD duration, serum PTH, T-score, and X-ray findings. Musculoskeletal system involvement remains a common problem which decreases the physical function of patients with ESRD.Keywords
This publication has 24 references indexed in Scilit:
- Factors associated with chronic musculoskeletal pain in patients with chronic kidney diseaseBMC Nephrology, 2014
- Chronic kidney disease: global dimension and perspectivesThe Lancet, 2013
- Prevalence of Renal Osteodystrophy in African Hemodialysis PatientsNephro-Urology Monthly, 2013
- Advanced Glycation End Products and β2-Microglobulin as Predictors of Carpal Tunnel Syndrome in Hemodialysis PatientsBlood Purification, 2012
- Neurological complications of hemodialysis: state of the artJournal of Nephrology, 2011
- Clinical implication of metabolic syndrome on chronic kidney disease depends on gender and menopausal status: results from the Korean National Health and Nutrition Examination SurveyNephrology Dialysis Transplantation, 2009
- Spontaneous Tendon Ruptures in Patients with End-Stage Renal DiseaseKidney and Blood Pressure Research, 2009
- Metabolic Bone Disease in Chronic Kidney DiseaseJournal of the American Society of Nephrology, 2007
- Obesity and Risk for Chronic Renal FailureJournal of the American Society of Nephrology, 2006
- Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)Kidney International, 2006