Inhibition of T‐Cell Activity by Cyclosporin A
- 1 May 1982
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 15 (5), 449-458
- https://doi.org/10.1111/j.1365-3083.1982.tb00670.x
Abstract
Cyclosporin A (CyA) inhibits early events in the T-ccll response. It strongly suppresses the activation of naive T cells by IL1 or IL2 and alloantigen. CyA exerts a selective effect on activ ated T cells, It inhibits the ability of these cells to release IL2 in response to antigen or mitogen restimulation, at concentrations that have no effect on the ability of these same cell populations to respond to IL2 by proliferation. The specific effects of CyA are not limited to T cells, however, and this drug will inhibit IL1 production by lipopolysaccharide W-stimulated PU5-IR cells.This publication has 29 references indexed in Scilit:
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