Computational models of neuron-astrocyte interaction in epilepsy
Open Access
- 1 January 2012
- journal article
- Published by Frontiers Media SA in Frontiers in Computational Neuroscience
- Vol. 6, 58
- https://doi.org/10.3389/fncom.2012.00058
Abstract
Astrocytes actively shape the dynamics of neurons and neuronal ensembles by affecting several aspects critical to neuronal function, such as regulating synaptic plasticity, modulating neuronal excitability, and maintaining extracellular ion balance. These pathways for astrocyte-neuron interaction can also enhance the information-processing capabilities of brains, but in other circumstances may lead the brain on the road to pathological ruin. In this article, we review the existing computational models of astrocytic involvement in epileptogenesis, focusing on their relevance to existing physiological data.Keywords
This publication has 73 references indexed in Scilit:
- Pattern of trauma determines the threshold for epileptic activity in a model of cortical deafferentationProceedings of the National Academy of Sciences of the United States of America, 2011
- Astroglial networks scale synaptic activity and plasticityProceedings of the National Academy of Sciences of the United States of America, 2011
- Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and BehaviorAnnual Review of Physiology, 2010
- Molecular dissection of reactive astrogliosis and glial scar formationTrends in Neurosciences, 2009
- Differences in Cortical versus Subcortical GABAergic Signaling: A Candidate Mechanism of Electroclinical Uncoupling of Neonatal SeizuresNeuron, 2009
- Spatiotemporal characteristics of calcium dynamics in astrocytesChaos: An Interdisciplinary Journal of Nonlinear Science, 2009
- The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamicsJournal of Computational Neuroscience, 2009
- The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: II. Network and glial dynamicsJournal of Computational Neuroscience, 2008
- Epileptogenesis due to glia-mediated synaptic scalingJournal of The Royal Society Interface, 2008
- Models of astrocytic Ca2+ dynamics and epilepsyDrug Discovery Today: Disease Models, 2008