Bacterial Infection and Implant Loosening in Hip and Knee Arthroplasty: Evaluation of 209 Cases
Open Access
- 26 October 2016
- Vol. 9 (11), 871
- https://doi.org/10.3390/ma9110871
Abstract
The aim of this study was to evaluate bacteria species detected in a large number of patients treated for prosthetic joint infection of the hip and knee at a single specialized center. Furthermore, the rate of implant loosening was investigated in a time-dependent manner for the most frequently detected bacteria species. A retrospective analysis of patients (n = 209) treated for prosthetic joint infection of the hip and knee was performed. The following parameters were evaluated: C-Reactive Protein (CRP) concentration, microbiological evaluation of tissue samples, loosening of the implant, the time that had elapsed since the primary prosthetic joint replacement, and the duration since the last surgical intervention. Coagulase-negative Staphylococcus spp. were most frequently detected, followed by Staphylococcus aureus. Differences in CRP concentration were detected among various bacteria species. Osteolysis was not associated with one causative agent in particular. Patients who had undergone previous revision surgery had a higher probability of implant loosening. Coagulase-negative Staphylococcus spp. are the most common causative agents of prosthetic joint infection and show no significant differences with regard to implant loosening or the time-course when compared to S. aureus. Infections with Enterococcus spp. seem to develop faster than with other bacteria species. The risk of implant loosening increases with revision surgery, in particular in the hip joint.Keywords
This publication has 34 references indexed in Scilit:
- Staphylococcus Lugdunensis, An Aggressive Coagulase-Negative Pathogen not to be UnderestimatedThe International Journal of Artificial Organs, 2012
- Increasing risk of prosthetic joint infection after total hip arthroplastyActa Orthopaedica, 2012
- A Large Multicenter Study of Methicillin–Susceptible and Methicillin–Resistant Staphylococcus aureus Prosthetic Joint Infections Managed With Implant RetentionClinical Infectious Diseases, 2012
- Economic Impact of Infected Total Knee ArthroplastyThe Scientific World Journal, 2012
- The microbiology of the infected knee arthroplastyInternational Orthopaedics, 2009
- Microbiology of the infected knee arthroplasty: Report from the Swedish Knee Arthroplasty Register on 426 surgically revised casesScandinavian Journal of Infectious Diseases, 2009
- Outcome of Enterococcal Prosthetic Joint Infection: Is Combination Systemic Therapy Superior to Monotherapy?Clinical Infectious Diseases, 2008
- Sonication of Removed Hip and Knee Prostheses for Diagnosis of InfectionThe New England Journal of Medicine, 2007
- Proposal for a histopathological consensus classification of the periprosthetic interface membraneJournal of Clinical Pathology, 2006
- Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic jointsAnz Journal of Surgery, 2004