Impact of renal function on survival after transcatheter aortic valve implantation (TAVI): an analysis of the UK TAVI registry
- 12 January 2015
- Vol. 101 (7), 546-552
- https://doi.org/10.1136/heartjnl-2014-307041
Abstract
Objective To determine the nature of the association between renal dysfunction and outcomes following transcatheter aortic valve implantation (TAVI) in all cases performed in the UK between 2007 and 2012. Methods The UK TAVI registry was established to report outcomes on all TAVI procedures performed within the UK. Data were collected prospectively on 3980 patients from 1 January 2007 until 31 December 2012. Results In total, 205 patients (5.5%) died during their admission. Moderate to advanced chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) <45 mL/min/1.73 m2) was significantly associated with increased mortality, even after adjustment for risk factors (OR 1.45, 95% CI 1.03 to 2.05; p=0.04). For every 10 mL/min/1.73 m2 decrease in eGFR, in-hospital mortality increased by 8.2% (95% CI 1.1% to 14.7%; p=0.03). In total 1119 patients (30.2%) died during the follow-up period (median 543 days). Moderate to advanced CKD (eGFR <45 mL/min/1.73 m2) was significantly associated with increased mortality, even after adjustment for risk factors (OR 1.36, 95% CI 1.17 to 1.58; p0.6. Conclusions Pre-procedural renal dysfunction is associated, in a graded fashion independently of dialysis status, with worse outcomes, including mortality in patients undergoing TAVI.Keywords
This publication has 21 references indexed in Scilit:
- Prognostic Value of Chronic Kidney Disease After Transcatheter Aortic Valve ImplantationJournal of the American College of Cardiology, 2013
- The UK transcatheter aortic valve implantation registry; one of the suite of registries hosted by the National Institute for Cardiovascular Outcomes Research (NICOR)Heart, 2012
- Are bioprostheses associated with better outcome than mechanical valves in patients with chronic kidney disease requiring dialysis who undergo valve surgery?Interactive CardioVascular and Thoracic Surgery, 2012
- Two-Year Outcomes after Transcatheter or Surgical Aortic-Valve ReplacementThe New England Journal of Medicine, 2012
- Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis: The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) RegistryJournal of the American College of Cardiology, 2011
- Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysisThe Lancet, 2010
- Arterial stiffness in chronic kidney disease: causes and consequencesHeart, 2010
- The relationship between renal function and outcome from heart valve surgeryAmerican Heart Journal, 2008
- Using Standardized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration RateAnnals of Internal Medicine, 2006
- Outcome of Patients With Low Ejection Fraction Undergoing Coronary Artery Bypass GraftingCirculation, 2006