Trends in AIDS-Defining and Non--AIDS-Defining Malignancies among HIV-Infected Patients: 1989-2002

Abstract

In a comparison of rates of acquired immunodeficiency syndrome (AIDS)–defining malignancies (ADMs) for 1989–1996 versus 1997–2002, we found a decrease in ADMs (rate ratio, 0.31; P < .0001) and a significant increase in non—AIDS-defining malignancies (non-ADMs; rate ratio, 10.87; P < .0002). The mean CD4 cell count was lower among patients with ADMs than among those with non-ADMs. A longer duration of survival during highly active antiretroviral therapy might explain the increasing incidence of non-ADMs.