Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles
- 28 April 2011
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 40 (10), 5049-5067
- https://doi.org/10.1039/c1cs15004a
Abstract
The palladium-catalyzed cyanation of Ar–X (X = I, Br, Cl, OTf, and H) allows for an efficient access towards benzonitriles. After its discovery in 1973 and following significant improvements in recent decades, this methodology has become nowadays the most popular for preparation of substituted aromatic nitriles. In this critical review, we summarize the important developments in this area from 2000 until 2010 (151 references).Keywords
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