Histidine Biosynthesis
- 1 January 2011
- journal article
- Published by BioOne in The Arabidopsis Book
- Vol. 9, e0141
- https://doi.org/10.1199/tab.0141
Abstract
Histidine (His) is one of the standard amino acids in proteins, and plays a critical role in plant growth and development. The chemical properties of the imidazole side group allow His to participate in acid-base catalysis, and in the co-ordination of metal ions. Despite the biological importance of this molecule, His biosynthesis has been somewhat neglected in plants, in stark contrast to micro-organisms where the study of this pathway was fundamental in the discovery of operon structure and regulation by attenuation. With the recent isolation of histidinol-phosphate phosphatase, all the enzymes of His biosynthesis have now been identified in Arabidopsis, and several lines of evidence have implicated ATP-phosphoribosyl transferase (which catalyses the first committed step of the pathway) as playing an important role in the regulation of this pathway. However, little is known about the transcriptional regulation of the His biosynthetic genes, nor how demand for this amino acid is balanced with other metabolic requirements in plants. Similarly, the pathway of His catabolism has yet to be determined.Keywords
This publication has 64 references indexed in Scilit:
- The Missing Link in Plant Histidine Biosynthesis: Arabidopsismyoinositol monophosphatase-like2Encodes a Functional Histidinol-Phosphate PhosphatasePlant Physiology, 2009
- VTC4 Is a Bifunctional Enzyme That Affects Myoinositol and Ascorbate Biosynthesis in PlantsPlant Physiology, 2009
- Genevestigator V3: A Reference Expression Database for the Meta-Analysis of TranscriptomesAdvances in Bioinformatics, 2008
- Improving the Content of Essential Amino Acids in Crop Plants: Goals and OpportunitiesPlant Physiology, 2008
- Principal Transcriptional Programs Regulating Plant Amino Acid Metabolism in Response to Abiotic StressesPlant Physiology, 2008
- Higher biomass accumulation by increasing phosphoribosylpyrophosphate synthetase activity in Arabidopsis thaliana and Nicotiana tabacumPlant Biotechnology Journal, 2007
- Genetic Dissection of Histidine Biosynthesis in ArabidopsisPlant Physiology, 2007
- Arabidopsis Co-expression Tool (ACT): web server tools for microarray-based gene expression analysisNucleic Acids Research, 2006
- Arabidopsis LHT1 Is a High-Affinity Transporter for Cellular Amino Acid Uptake in Both Root Epidermis and Leaf MesophyllPlant Cell, 2006
- The hpa1 Mutant of Arabidopsis Reveals a Crucial Role of Histidine Homeostasis in Root Meristem MaintenancePlant Physiology, 2006