Darwinian Evolution of Prions in Cell Culture
- 12 February 2010
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5967), 869-872
- https://doi.org/10.1126/science.1183218
Abstract
DNA-less Evolution: Prions are proteinaceous infectious elements involved in a variety of neurodegenerative diseases, including scrapie in sheep and so-called mad cow disease in cattle. Now Li et al. (p. 869 , published online 31 December) show that, when propagated in tissue culture cells, cloned prion populations become diverse by mutational events and can undergo selective amplification. Thus, even though devoid of a coding genome, prions, when propagated under a particular selection regime, can be subject to rapid evolution.Keywords
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