Placental Transfer of Tritiated-1-Δ9-Tetrahydrocannabinol
- 7 August 1969
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 281 (6), 330
- https://doi.org/10.1056/nejm196908072810620
Abstract
To the Editor: The teratogenic action of cannabis extract in pregnant rats,1 hamsters2 and rabbits3 has been reported. It seems important to establish to what extent the major psychoactive component of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), can cross the placenta and when during pregnancy the fetus is exposed to its effect. l-Δ8-Tetrahydrocannabinol (Δ8-THC) prepared according to the procedure of Mechoulam et al.4 was labeled with the use of a tritium-hydrogen exchange reaction. The purified Δ8-THC-H3 was converted into a mixture of Δ8-and Δ9-THC-H3 as previously reported,4 , 5 and the Δ9-isomer was separated by column chromatography . . .This publication has 4 references indexed in Scilit:
- Effect of marihuana extract on fetal hamsters and rabbitsToxicology and Applied Pharmacology, 1969
- TERATOGENIC ACTIVITY OF CANNABIS RESINThe Lancet, 1968
- Total synthesis of (.+-.)-.DELTA.9-tetrahydrocannabinol and four of its isomersJournal of the American Chemical Society, 1967
- Stereospecific synthesis of (-)-.DELTA.1- and (-)-.DELTA.1(6)-tetrahydrocannabinolsJournal of the American Chemical Society, 1967