The Aging Gut Motility Decay: May Symbiotics Be Acting as "Implantable" Biologic Pace-Makers?
- 1 June 2006
- journal article
- research article
- Published by Mary Ann Liebert Inc in Rejuvenation Research
- Vol. 9 (2), 342-345
- https://doi.org/10.1089/rej.2006.9.342
Abstract
Motility recording of small and large intestine was performed in old Wistar rats divided into three groups: (a) standard diet, (b) standard diet plus a symbiotic preparation, and (c) standard diet plus a heat-inactivated symbiotic preparation. SCM-III. significantly increased the myoelectric activity of small intestine and colon (p < 0.01 versus [a] and [c]) paralleling "young" values of 4-month-old rats and increased the spike burst frequency in the proximaldistal colon (p < 0.05). SCM-III significantly increased the frequency and duration of spike bursts in the jejunum, transverse-distal colon, and defecation frequency, while decreasing the intervals of migrating motor complex in the colon (p < 0.01) to "young" values with an increased mRNA expression of VIP (p < 0.05). Gut flora manipulation aimed to modulate myoelectric activity can tentatively help reversing age-related motility decay.Keywords
This publication has 19 references indexed in Scilit:
- Comparison of Compositions and Metabolic Activities of Fecal Microbiotas in Young Adults and in Antibiotic-Treated and Non-Antibiotic-Treated Elderly SubjectsApplied and Environmental Microbiology, 2004
- Postinfectious irritable bowel syndrome1 1Abbreviations used in this paper: EC,_; IBS, irritable bowel syndrome; PI, postinfective.Gastroenterology, 2003
- Aging and Intestinal MotilityDrugs & Aging, 2002
- Differences in Composition and Mucosal Adhesion of Bifidobacteria Isolated from Healthy Adults and Healthy SeniorsCurrent Microbiology, 2001
- Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profilesGut, 2001
- Age-induced changes in the enteric nervous system in the mouseMechanisms of Ageing and Development, 1999
- Interdigestive and Postprandial Motility in Small-Intestinal Bacterial OvergrowthScandinavian Journal of Gastroenterology, 1996
- Introduction of conventional microbial flora to germfree rats increases the frequency of migrating myoelectric complexesNeurogastroenterology & Motility, 1992
- Altered myoelectric activity in the experimental blind loop syndrome.JCI Insight, 1983
- Effect of the Normal Microbial Flora on Gastrointestinal Motility.Experimental Biology and Medicine, 1967