Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse
Open Access
- 27 February 2008
- journal article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 28 (6), 1186-1195
- https://doi.org/10.1038/jcbfm.2008.8
Abstract
Uncoupling protein 2 (UCP2) is upregulated in the brain after sublethal ischemia, and overexpression of UCP2 is neuroprotective in several models of neurodegenerative disease. We investigated if in...Keywords
This publication has 43 references indexed in Scilit:
- A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2Cell Metabolism, 2007
- Uncoupling protein 2 negatively regulates neurite extensions in PC12h cellsNeuroscience Letters, 2006
- Effects of rosiglitazone on global ischemia-induced hippocampal injury and expression of mitochondrial uncoupling protein 2Biochemical and Biophysical Research Communications, 2006
- Uncoupling Protein 2 Has Protective Function during Experimental Autoimmune EncephalomyelitisThe American Journal of Pathology, 2006
- The Emerging Functions of UCP2 in Health, Disease, and TherapeuticsAntioxidants and Redox Signaling, 2006
- Mitochondrial uncoupling proteins in the cns: in support of function and survivalNature Reviews Neuroscience, 2005
- Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitroEuropean Journal of Neuroscience, 2004
- Uncoupling protein 2 in the brain: distribution and functionBiochemical Society Transactions, 2001
- Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene ExpressionStroke, 1998
- Phosphorylase a and Labile Metabolites During Anoxia: Correlation to Membrane Fluxes of K+ and Ca2+Journal of Neurochemistry, 1990