Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease
Open Access
- 1 November 2011
- journal article
- review article
- Published by Elsevier BV in Online Journal of Public Health Informatics
- Vol. 286 (45), 38825-38832
- https://doi.org/10.1074/jbc.r111.288308
Abstract
No abstract availableKeywords
This publication has 100 references indexed in Scilit:
- Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's diseaseThe EMBO Journal, 2011
- Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No HypogonadismJournal of Biological Chemistry, 2011
- Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD MiceOnline Journal of Public Health Informatics, 2011
- Alzheimer's Aβ Peptides with Disease-Associated N-Terminal Modifications: Influence of Isomerisation, Truncation and Mutation on Cu2+ CoordinationPLOS ONE, 2010
- Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer DiseaseOnline Journal of Public Health Informatics, 2010
- Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s diseaseActa Neuropathologica, 2010
- Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease casesJournal of Neural Transmission, 2009
- Developing novel immunogens for a safe and effective Alzheimer's disease vaccinePublished by Elsevier BV ,2009
- Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's diseaseProceedings of the National Academy of Sciences of the United States of America, 2009
- Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse modelActa Neuropathologica, 2009