New insights on the role of CD8+CD57+T-cells in cancer
Open Access
- 1 September 2012
- journal article
- Published by Informa UK Limited in OncoImmunology
- Vol. 1 (6), 954-956
- https://doi.org/10.4161/onci.20307
Abstract
Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8+CD57+ T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a terminally-differentiated effector cell. These cells behave as incompletely-differentiated CTLs.Keywords
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