Recent advances in ultra-small fluorescent Au nanoclusters toward oncological research
- 17 July 2019
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Nanoscale
- Vol. 11 (39), 17967-17980
- https://doi.org/10.1039/c9nr04301b
Abstract
Au nanoclusters possess a series of excellent properties owing to their size being comparable to the Fermi wavelength of electrons. For example, they show excellent biocompatibility, optical stability, large Stokes shift, intense size-dependent emission and monodispersion, and thus could effectively compensate for the shortcomings of traditional organic fluorescent dyes and fluorescent quantum. In this review, we detail the latest developments of Au nanoclusters employed in the field of biomedicine, especially in oncology research, by summarizing the application of imaging, sensing and drug delivery based on their excellent luminescent properties and unique structural features. We also discuss the significant work relating to Au NCs that now is being devoted in other therapeutic strategies, such as radiotherapy, photothermal therapy and photodynamic therapy, for example. It is anticipated that this review will provide new insights and theoretical guidance to allow the advantages of Au nanoclusters to be realized in oncotherapy.Keywords
Funding Information
- National Natural Science Foundation of China (51671114)
- Fundamental Research Fund of Shandong University (2018JC046, 2018JC047)
This publication has 149 references indexed in Scilit:
- Gold Nanocluster-Conjugated Amphiphilic Block Copolymer for Tumor-Targeted Drug DeliveryACS Applied Materials & Interfaces, 2012
- From Aggregation-Induced Emission of Au(I)–Thiolate Complexes to Ultrabright Au(0)@Au(I)–Thiolate Core–Shell NanoclustersJournal of the American Chemical Society, 2012
- Synthesis of Highly Fluorescent Metal (Ag, Au, Pt, and Cu) Nanoclusters by Electrostatically Induced Reversible Phase TransferACS Nano, 2011
- Insulin‐Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell ImagingAngewandte Chemie, 2011
- Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signalsChemical Society Reviews, 2011
- Rapid sonochemical synthesis of highly luminescent non-toxic AuNCs and Au@AgNCs and Cu (ii) sensingChemical Communications, 2011
- New Strategies for Fluorescent Probe Design in Medical Diagnostic ImagingChemical Reviews, 2009
- Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probesNature Medicine, 2008
- Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007Journal of Experimental & Clinical Cancer Research, 2008
- Tumour lysis syndrome: new therapeutic strategies and classificationBritish Journal of Haematology, 2004