Pathophysiology of Chronic Rhinosinusitis with Nasal Polyp
- 1 September 2011
- journal article
- review article
- Published by SAGE Publications in American Journal of Rhinology and Allergy
- Vol. 25 (5), 285-290
- https://doi.org/10.2500/ajra.2011.25.3680
Abstract
Background: Chronic rhinosinusitis (CRS) is a common inflammatory condition of the paranasal sinuses and nasal passages. CRS with nasal polyp (CRSwNP) is a subtype of CRS, and the pathogenesis of CRSwNP remains largely unclear.Methods: This article reviews the literature regarding the pathophysiology of CRSwNP.Results: Evidence suggests that altered innate immunity, adaptive immunity, tissue remodeling, and/or effects of microorganisms may play a role in the development of CRSwNP. Aberrant arachidonic acid metabolism may also contribute to the pathogenesis of CRSwNP in patients with aspirin-exacerbated respiratory disease.Conclusion: There have been significant advances in the understanding pathophysiology of CRSwNP. Additional research is needed to elucidate these mechanisms and to determine their relative importance in the pathogenesis of CRSwNP.Keywords
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