Specific Laboratory Test for Diagnosis of Multiple Sclerosis
- 9 March 1974
- Vol. 1 (5905), 412-414
- https://doi.org/10.1136/bmj.1.5905.412
Abstract
Lymphocytes from patients with multiple sclerosis are much more susceptible to the inhibitory activity of linoleic acid (0·08 mg/ml) when tested for sensitization to thyroid by the macrophage electrophoretic mobility test (91% inhibition) than are those from normal subjects (57% inhibition). Cells from patients with a variety of other neurological diseases give 47% inhibition with linoleic acid. These differences are specific for multiple sclerosis and can be used as an in-vitro diagnostic test for the disease. Nearly 43% of clinically normal near relatives of patients with multiple sclerosis show an “anomalous” figure of about 77%; in the remainder the figure is the same as in the general population (57%). An anomalous result is compatible with lifelong freedom from M.S. Possibly a congenital anomalous handling of unsaturated fatty acids is a constant feature of the disease.Keywords
This publication has 11 references indexed in Scilit:
- Unsaturated fatty acids in multiple sclerosis.BMJ, 1973
- Double-blind Trial of Linoleate Supplementation of the Diet in Multiple SclerosisBMJ, 1973
- Specific Lymphocyte Sensitization in Cancer: Is There a Common Antigen in Human Malignant Neoplasia?BMJ, 1971
- LYMPHOCYTE SENSITISATION: AN IN-VITRO TEST FOR CANCER ?The Lancet, 1970
- Fatty acid composition of phospholipids from platelets and erythrocytes in multiple sclerosisJournal of Neurology, Neurosurgery & Psychiatry, 1970
- CIRCULATING SENSITISED LYMPHOCYTES IN GRAVES' DISEASE OBSERVATIONS ON ITS PATHOGENESISThe Lancet, 1970
- Sensitization of Blood Lymphocytes to Possible Antigens in Neurological DiseaseEuropean Neurology, 1970
- Lymphocyte Transformation in vitro Measured by Tritiated Thymidine UptakeInternational Archives of Allergy and Immunology, 1970
- ALLERGIC ENCEPHALOMYELITIS INDUCED BY BRAIN ANTIGEN AFTER DEFICIENCY IN POLYUNSATURATED FATTY ACIDS DURING MYELINATIONActa Neurologica Scandinavica, 1967
- RESPONSE OF HUMAN BLOOD LYMPHOCYTES TO TUBERCULIN PPD IN TISSUE CULTURE1967