Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster
Open Access
- 1 January 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journals of Gerontology: Series A
- Vol. 59 (1), B3-B9
- https://doi.org/10.1093/gerona/59.1.b3
Abstract
Dietary restriction (DR) has been shown to increase life span in taxonomically diverse animal species. In this study we tested for sex differences in the response of life span to graded severity of DR in Drosophila melanogaster. In both sexes, life span peaked at an intermediate food concentration and declined on either side. However, the magnitude of the response and the food concentration that minimized adult mortality differed significantly between the sexes. Female life span peaked at a food concentration 60% of the standard laboratory diet compared to a concentration of 40% for males. Moreover, female flies subject to DR lived up to 60% longer than did starved or fully fed females, whereas males subjected to DR lived only up to 30% longer. Analysis of age-specific mortality rates showed that DR extended life span by decreasing baseline mortality rates in both sexes, and to a greater extent in females. The differences in the response to DR in female and male Drosophila may be due to previously documented sex differences in sensitivity of life span to insulin/insulin-like growth factor-1 signalling or in nutrient/energy demand and allocation/utilization.Keywords
This publication has 42 references indexed in Scilit:
- Demography of Dietary Restriction and Death in DrosophilaScience, 2003
- IGF-1 receptor regulates lifespan and resistance to oxidative stress in miceNature, 2002
- Mechanisms of aging: public or private?Nature Reviews Genetics, 2002
- Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional ConditionsDevelopmental Cell, 2002
- Metabolic control and ageingTrends in Genetics, 2000
- Model fitting and hypothesis testing for age-specific mortality dataJournal of Evolutionary Biology, 1999
- A C. elegans mutant that lives twice as long as wild typeNature, 1993
- Metabolic fuels and reproduction in female mammalsNeuroscience & Biobehavioral Reviews, 1992
- Retardation of the Aging Processes in Rats by Food RestrictionAnnals of the New York Academy of Sciences, 1991
- Quantitative under-feeding of drosophila: Effects on adult longevity and fecundityExperimental Gerontology, 1971