Type-1 and type-2 angiotensin II receptors in fetal rat brain
- 30 May 1991
- journal article
- research article
- Published by Elsevier BV in European Journal of Pharmacology
- Vol. 198 (1), 89-92
- https://doi.org/10.1016/0014-2999(91)90566-9
Abstract
Brain angiotensin II receptors were located in 18-day-old rat embryos by quantitative autoradiography. In the nucleus of the solitary tract and choroid plexus, binding was displaced by the type-1 antagonist DuP 753. In the inferior olive, paratrigeminal and hypoglossal nuclei, binding was displaced by the type-2 antagonist CGP 42112 A. Meninges and cephalic soft tissues contained predominantly type-2 angiotensin II receptors. Our results indicate a role for type-1 and type-2 angiotensin II receptors during brain development.Keywords
This publication has 7 references indexed in Scilit:
- DIFFERENTIAL DEVELOPMENT OF ANGIOTENSIN II RECEPTOR SUBTYPES IN THE RAT BRAINEndocrinology, 1991
- Quantitative Autoradiography Reveals Different Angiotensin II Receptor Subtypes in Selected Rat Brain NucleiJournal of Neurochemistry, 1991
- Identification of angiotensin II receptor subtypesBiochemical and Biophysical Research Communications, 1989
- Preliminary biochemical characterization of two angiotensin II receptor subtypesBiochemical and Biophysical Research Communications, 1989
- Ontogeny of renin‐induced salt appetite in the rat pupDevelopmental Psychobiology, 1989
- Novel Sites of Expression of Functional Angiotensin II Receptors in the Late Gestation FetusScience, 1989
- Binding of angiotensin and atrial natriuretic peptide in brain of hypertensive ratsNature, 1986