Intracellular Events in the Initiation of Calcium Oxalate Stones
- 1 October 2004
- journal article
- review article
- Published by S. Karger AG in Nephron Experimental Nephrology
- Vol. 98 (2), e61-e64
- https://doi.org/10.1159/000080258
Abstract
This review summarizes our current understanding of intracellular events in the initiation of kidney stone formation, focusing on results from studies using renal epithelial cells in vitro. Such studies have shown that oxalate - either in crystalline or in soluble form - triggers a spectrum of responses in renal cells that favor stone formation, including alterations in membrane surface properties that promote crystal attachment and alterations in cell viability that provide debris for crystal nucleation. Activation of cytosolic PLA2 appears to play an important role in oxalate actions, triggering a signaling cascade that generates several lipid mediators (arachidonic acid, AA; lysophosphatidylcholine, Lyso-PC; ceramide) that act on key intracellular targets (mitochondria, nucleus). The net effect is increased production of reactive oxygen molecules (that in turn affect other cellular processes), an increase in cell death and an induction of a number of genes in surviving cells, some of which may promote proliferation for replacement of damaged cells, or may promote secretion of urinary macromolecules that serve to modulate crystal formation. A scheme is provided that explains how such oxalate-induced alterations could initiate stone formation in vivo.This publication has 22 references indexed in Scilit:
- Osteopontin—a molecule for all seasonsQJM: An International Journal of Medicine, 2002
- Oxalate-Induced Redistribution of Phosphatidylserine in Renal Epithelial CellsAmerican Journal of Nephrology, 2001
- Plasma phospholipid arachidonic acid content and calcium metabolism in idiopathic calcium nephrolithiasisKidney International, 2000
- FREE RADICAL SCAVENGERS, CATALASE AND SUPEROXIDE DISMUTASE PROVIDE PROTECTION FROM OXALATE-ASSOCIATED INJURY TO LLC-PK1 AND MDCK CELLSJournal of Urology, 2000
- Oxalate-induced ceramide accumulation in Madin-Darby canine kidney and LLC-PK1 cellsKidney International, 2000
- New insights into the pathogenesis of membranous nephropathyKidney International, 2000
- Oxalate Toxicity in Renal Epithelial Cells: Characteristics of Apoptosis and NecrosisToxicology and Applied Pharmacology, 2000
- Decreased Plasma Insulin-Like Growth Factor-I Level in Familial Alzheimer’s Disease Patients Carrying the Swedish APP 670/671 MutationDementia and Geriatric Cognitive Disorders, 1999
- REGULATION OF CERAMIDE PRODUCTION AND APOPTOSISAnnual Review of Physiology, 1998
- The growing phospholipase A2 superfamily of signal transduction enzymesTrends in Biochemical Sciences, 1997