Exploring Staphylococcus aureus pathways to disease for vaccine development
Open Access
- 1 December 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Seminars in Immunopathology
- Vol. 34 (2), 317-333
- https://doi.org/10.1007/s00281-011-0299-z
Abstract
Staphylococcus aureus is a commensal of the human skin or nares and a pathogen that frequently causes skin and soft tissue infections as well as bacteremia and sepsis. Recent efforts in understanding the molecular mechanisms of pathogenesis revealed key virulence strategies of S. aureus in host tissues: bacterial scavenging of iron, induction of coagulation pathways to promote staphylococcal agglutination in the vasculature, and suppression of innate and adaptive immune responses. Advances in all three areas have been explored for opportunities in vaccine design in an effort to identify the critical protective antigens of S. aureus. Human clinical trials with specific subunit vaccines have failed, yet provide important insights for the design of future trials that must address the current epidemic of S. aureus infections with drug-resistant isolates (MRSA, methicillin-resistant S. aureus).Keywords
This publication has 156 references indexed in Scilit:
- In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activationNature Medicine, 2011
- IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challengeVaccine, 2010
- Community-associated meticillin-resistant Staphylococcus aureusThe Lancet, 2010
- Waves of resistance: Staphylococcus aureus in the antibiotic eraNature Reviews Microbiology, 2009
- Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitorNature Immunology, 2009
- Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombinProceedings of the National Academy of Sciences of the United States of America, 2009
- Complement evasion by human pathogensNature Reviews Microbiology, 2008
- A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates VirulenceCell Host & Microbe, 2007
- Vaccine assembly from surface proteins ofStaphylococcus aureusProceedings of the National Academy of Sciences of the United States of America, 2006
- Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureusProceedings of the National Academy of Sciences of the United States of America, 2002