Function of the Respiratory Syncytial Virus Small Hydrophobic Protein
- 1 August 2007
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 81 (15), 8361-8366
- https://doi.org/10.1128/jvi.02717-06
Abstract
Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function. Parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, also encodes an SH protein, which inhibits tumor necrosis factor alpha (TNF-α) signaling. In this study, recombinant PIV5 viruses without their own SH but containing RSV SH (from RSV strain A2 or B1) in its place (PIV5ΔSH-RSV SH) and RSV lacking its own SH (RSVΔSH) were generated and analyzed. The results indicate that the SH protein of RSV has a function similar to that of PIV5 SH and that it can inhibit TNF-α signaling.Keywords
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