Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: preclinical and clinical observations
- 3 July 2012
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Food & Function
- Vol. 3 (11), 1109-1117
- https://doi.org/10.1039/c2fo30097d
Abstract
Inflammatory bowel disease (IBD) comprising of ulcerative colitis (UC) and Crohn's disease (CD) is a major ailment affecting the small and large bowel. In clinics, IBD is treated using 5-amninosalicylates, antibiotics, the steroids and immunomodulators. Unfortunately, the long term usages of these agents are associated with undue side effects and compromise the therapeutic advantage. Accordingly, there is a need for novel agents that are effective, acceptable and non toxic to humans. Preclinical studies in experimental animals have shown that curcumin, an active principle of the Indian spice turmeric (Curcuma longa Linn) is effective in preventing or ameliorating UC and inflammation. Over the last few decades there has been increasing interest in the possible role of curcumin in IBD and several studies with various experimental models of IBD have shown it to be effective in mediating the inhibitory effects by scavenging free radicals, increasing antioxidants, influencing multiple signaling pathways, especially the kinases (MAPK, ERK), inhibiting myeloperoxidase, COX-1, COX-2, LOX, TNF-α, IFN-γ, iNOS; inhibiting the transcription factor NF-κB. Clinical studies have also shown that co-administration of curcumin with conventional drugs was effective, to be well-tolerated and treated as a safe medication for maintaining remission, to prevent relapse and improve clinical activity index. Large randomized controlled clinical investigations are required to fully understand the potential of oral curcumin for treating IBD.Keywords
This publication has 50 references indexed in Scilit:
- Curcumin inhibits interferon-γ signaling in colonic epithelial cellsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2012
- Counteracting effect of TRPC1-associated Ca2+influx on TNF-α-induced COX-2-dependent prostaglandin E2production in human colonic myofibroblastsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2011
- Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer TreatmentMolecules, 2011
- Pharmacological regulation of neutrophil activity and apoptosisInterdisciplinary Toxicology, 2011
- Mitogen activated protein kinases: a role in inflammatory bowel disease?Clinical and Experimental Immunology, 2009
- Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protectionAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2008
- Expression of peroxisome proliferator-activated receptor-γ in macrophage suppresses experimentally induced colitisAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2007
- Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitisActa Pharmacologica Sinica, 2006
- Curcumin Therapy in Inflammatory Bowel Disease: A Pilot StudyDigestive Diseases and Sciences, 2005
- Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel diseaseDigestive Diseases and Sciences, 1996