Fast multislice mapping of the myelin water fraction using multicompartment analysis of T decay at 3T: A preliminary postmortem study
Open Access
- 29 October 2007
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 58 (5), 865-870
- https://doi.org/10.1002/mrm.21409
Abstract
Quantitative mapping of the myelin water content can provide significant insight into the pathophysiology of several white matter diseases, such as multiple sclerosis and leukoencephalopathies, and can potentially become a useful clinical tool for early diagnosis of these diseases. In this study, multicompartment analysis of T decay (MCAT2*) was used for the quantitative mapping of myelin water fraction (MWF). T decay of each voxel at multiple slice locations was acquired in fixed human brains using a multigradient-echo (MGRE) pulse sequence with alternating readout gradient polarities. Compared to prior techniques using Carr-Purcell-Meiboom-Gill (CPMG) acquisition, the MGRE acquisition approach has: 1) a very short first echo time (≈2 ms) and echo-spacing (≈1 ms), which allows for the acquisition of multiple sampling points during the fast decay of the myelin water signal; 2) a low RF duty cycle, which is especially important for achieving acceptable specific absorption rate (SAR) levels at high field strengths. Multicompartment analysis was then applied to the T decay in each pixel using a 3-pool model of white matter to detect the signal arising from the myelin water, myelinated axonal water, and mixed water compartments. Magn Reson Med 58:865–870, 2007.Keywords
This publication has 18 references indexed in Scilit:
- Testing the three‐pool white matter model adapted for use with T2 relaxometryMagnetic Resonance in Medicine, 2005
- Linear combination of multiecho data: Short T2 component selectionMagnetic Resonance in Medicine, 2004
- Reduction of spectral ghost artifacts in high‐resolution echo‐planar spectroscopic imaging of water and fat resonancesMagnetic Resonance in Medicine, 2003
- Three‐pool model of white matterJournal of Magnetic Resonance Imaging, 2002
- Normal‐appearing white matter in multiple sclerosis has heterogeneous, diffusely prolonged T2Magnetic Resonance in Medicine, 2002
- In vivo visualization of myelin water in brain by magnetic resonanceMagnetic Resonance in Medicine, 1994
- Practical T2 quantitation for clinical applicationsJournal of Magnetic Resonance Imaging, 1992
- Parameter relations for the Shinnar-Le Roux selective excitation pulse design algorithm (NMR imaging)IEEE Transactions on Medical Imaging, 1991
- Quantitative interpretation of NMR relaxation dataJournal of Magnetic Resonance (1969), 1989
- NMR population inversion using a composite pulseJournal of Magnetic Resonance (1969), 1979