Trends in colorectal cancer incidence: a period and birth-cohort analysis in a well-defined French population
Open Access
- 30 June 2011
- journal article
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 11 (1), 282
- https://doi.org/10.1186/1471-2407-11-282
Abstract
Background France stands among high-risk areas for colorectal cancer. Different trends in CRC incidence are reported around the world. The aim of this study was to provide temporal trends in CRC incidence over a 30-year period in a French well-defined population. Methods Between 1976 and 2005, 17,028 new cases were registered by the Burgundy digestive cancer registry. The mean variations in age-standardized incidence rates were estimated using a Poisson regression adjusted for age for each gender and location. The cumulative risk by birth cohort of developing a cancer over the age range 0-74 years was estimated using an age-cohort model. Results Incidence rates for right and left colon cancers increased more rapidly in males (respectively +11.7% and +10.3% on average by 5-year period) than in females (respectively +5.9% and +6.1%). It remained stable for sigmoid cancers in males (-0.1%) and decreased in females (-5.2%). It also decreased for rectal cancers both in males (-2.7%) and in females (-2.0%). The cumulative risk increased from 3.9% for males born around 1900 to 4.9% for those born around 1930 and then slightly decreased (4.5% among those born around 1950). It remained at the same level for females born around 1900 (2.7%) as for those born around 1930 (2.7%) and then slightly increased (2.9%) for those born around 1950. For right colon cancers, the cumulative risk increased strikingly in successive birth cohorts from 0.53% to 1.2% in males and 0.55% to 0.77% in females. The corresponding cumulative risks for the left colon were 0.24% and 0.42% in males and 0.14% and 0.29% in females. For sigmoid cancer, they decreased from 1.59% to 1.08% in males, and 0.88% to 0.80% in females. Conclusion Temporal variations in incidence rates of colorectal cancers differed according to subsite, suggesting different aetiological factors and implications for diagnosis and screening strategies. Total colonoscopy must be the preferred strategy in high-risk groups or after a positive faecal occult blood test.Keywords
This publication has 24 references indexed in Scilit:
- Annual report to the nation on the status of cancer, 1975‐2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future ratesCancer, 2009
- Trends in colorectal cancer incidence in Norway 1962–2006: an interpretation of the temporal patterns by anatomic subsiteInternational Journal of Cancer, 2009
- International Trends in Colorectal Cancer Incidence RatesCancer Epidemiology, Biomarkers & Prevention, 2009
- Secular changes in colorectal cancer incidence by subsite, stage at diagnosis, and race/ethnicity, 1992–2001Cancer, 2006
- Colorectal Cancer in Denmark 1943-1997Diseases of the Colon & Rectum, 2004
- Increasing colorectal cancer incidence rates in JapanInternational Journal of Cancer, 2004
- Foods as risk factors for colorectal cancer: a case–control study in Burgundy (France)European Journal Of Cancer Prevention, 1999
- Age‐period‐cohort modelling of large‐bowel‐cancer incidence by anatomic sub‐site and sex in connecticutInternational Journal of Cancer, 1993
- Epidemiological evidence for distinguishing subsites of colorectal cancer.Journal of Epidemiology and Community Health, 1989
- Models for temporal variation in cancer rates. II: Age–period–cohort modelsStatistics in Medicine, 1987