Treatment of Chronic Elbow Tendinosis with Buffered Platelet-Rich Plasma
Top Cited Papers
- 1 November 2006
- journal article
- research article
- Published by SAGE Publications in The American Journal of Sports Medicine
- Vol. 34 (11), 1774-1778
- https://doi.org/10.1177/0363546506288850
Abstract
Background Elbow epicondylar tendinosis is a common problem that usually resolves with nonoperative treatments. When these measures fail, however, patients are interested in an alternative to surgical intervention. Hypothesis Treatment of chronic severe elbow tendinosis with buffered platelet-rich plasma will reduce pain and increase function in patients considering surgery for their problem. Study Design Cohort study; Level of evidence, 2. Methods One hundred forty patients with elbow epicondylar pain were evaluated in this study. All these patients were initially given a standardized physical therapy protocol and a variety of other nonoperative treatments. Twenty of these patients had significant persistent pain for a mean of 15 months (mean, 82 of 100; range, 60-100 of 100 on a visual analog pain scale), despite these interventions. All patients were considering surgery. This cohort of patients who had failed nonoperative treatment was then given either a single percutaneous injection of platelet-rich plasma (active group, n = 15) or bupivacaine (control group, n = 5). Results Eight weeks after the treatment, the platelet-rich plasma patients noted 60% improvement in their visual analog pain scores versus 16% improvement in control patients (P =. 001). Sixty percent (3 of 5) of the control subjects withdrew or sought other treatments after the 8-week period, preventing further direct analysis. Therefore, only the patients treated with platelet-rich plasma were available for continued evaluation. At 6 months, the patients treated with platelet-rich plasma noted 81% improvement in their visual analog pain scores (P =. 0001). At final follow-up (mean, 25.6 months; range, 12-38 months), the platelet-rich plasma patients reported 93% reduction in pain compared with before the treatment (P <. 0001). Conclusion Treatment of patients with chronic elbow tendinosis with buffered platelet-rich plasma reduced pain significantly in this pilot investigation. Further evaluation of this novel treatment is warranted. Finally, platelet-rich plasma should be considered before surgical intervention.Keywords
This publication has 18 references indexed in Scilit:
- Biomechanical Basis for TendinopathyClinical Orthopaedics & Related Research, 2006
- Treatment of Recalcitrant Lateral Epicondylitis with Suture Anchor RepairThe American Journal of Sports Medicine, 2005
- Platelet-Derived Growth Factor Inhibits Demineralized Bone Matrix-Induced Intramuscular Cartilage and Bone FormationThe Journal of Bone & Joint Surgery, 2005
- The Roles of Growth Factors in Tendon and Ligament HealingSports Medicine, 2003
- Effectiveness of physiotherapy for lateral epicondylitis: a systematic reviewAnnals of Medicine, 2003
- Botulinum Toxin Injection Versus Surgical Treatment for Tennis ElbowPublished by Ovid Technologies (Wolters Kluwer Health) ,2002
- Local Injection Treatment for Lateral EpicondylitisClinical Orthopaedics and Related Research, 2002
- Platelet-rich plasmaOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 1998
- Involvement of platelets in stimulating osteogenic activityJournal of Orthopaedic Research, 1995
- ABNORMAL MICROVASCULAR RESPONSES IN LATERAL EPICONDYLITISRheumatology, 1994