Neonatal Isoimmune Thrombocytopenia
- 1 March 1984
- journal article
- Published by SAGE Publications in Clinical Pediatrics
- Vol. 23 (3), 159-162
- https://doi.org/10.1177/000992288402300305
Abstract
Isoimmune neonatal thrombocytopenia purpura (INTP) is a disease caused by platelet destruction by maternally derived antibody. Six patients were investigated. Maternal derived platelet trans fusions in two patients resulted in posttransfusion platelet counts of greater than 85,000/μl, a normal platelet survival of 7 to 10 days, and an early discharge from the hospital. In four patients, random donor platelet transfusions administered in the first week caused a transient rise of between 7 and 30,000 platelets per μl with a return to pretransfusion levels 24 to 48 hours later, confirming the ineffectiveness of this form of treatment. Corticosteroid therapy is not effective and because of its potential toxicity should not be recommended for use in INTP. Platelet antigen was identified in the parents, and maternal sensitization was proven by the presence of platelet specific antibody. Severity of the disorder was estimated by the initial platelet count and the duration in weeks for the platelet count to rise above 100,000/ μl. Lymphocytotoxicity and immune lysis, as measured by the51Chromium release assay, did not show an obvious relationship with the severity of the disorder. In our patients, high scores in the platelet suspension immunofluo rescence test related to a more severe disorder, but a larger series would be necessary to confirm this finding.Keywords
This publication has 10 references indexed in Scilit:
- Neonatal alloimmune thrombocytopenia: detection and characterization of the responsible antibodies by the platelet immunofluorescence testBlood, 1981
- A Simple Immunofluorescence Test for the Detection of Platelet AntibodiesBritish Journal of Haematology, 1978
- Neonatal ThrombocytopeniaClinics in Haematology, 1978
- Detection of drug-dependent antibodies by the51cr platelet lysis test: Documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazoleAmerican Journal of Hematology, 1977
- Management of isoimmune neonatal thrombocytopeniaAmerican Journal of Obstetrics and Gynecology, 1976
- Neonatal isoimmune purpura: Response to platelet infusionsThe Journal of Pediatrics, 1973
- Use of Compatible Platelet Transfusions in Treatment of Congenital Isoimmune Thrombocytopenic PurpuraNew England Journal of Medicine, 1969
- Isoimmune Neonatal Thrombocytopenic PurpuraBlood, 1964
- NEONATAL THROMBOCYTOPENIC PURPURAPEDIATRICS, 1962
- IMMUNOREACTIONS INVOLVING PLATELETS. VI. REACTIONS OF MATERNAL ISOANTIBODIES RESPONSIBLE FOR NEONATAL PURPURA. DIFFERENTIATION OF A SECOND PLATELET ANTIGEN SYSTEM*JCI Insight, 1962