Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [18F]Fluorodeoxyglucose and [11C]Deoxyglucose

Abstract

The rate constants and lumped constants (LCs) for [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) and [¹¹C]deoxyglucose ([¹¹C]DG) were determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption. The mean values (±SE) of the LCs for [¹⁸F]FDG and [¹¹C]DG are 0.52 ± 0.028 (n = 9) and 0.56 ± 0.043 (n = 6), respectively. The mean values (±SE) of the rate constants k*₁, k*₂, k*₃, and k*₄ for [¹⁸F]FDG for gray matter are 0.095 ± 0.005, 0.125 ± 0.002, 0.069 ± 0.002, and 0.0055 ± 0.0003, respectively. The corresponding values for white matter are 0.065 ± 0.005, 0.126 ± 0.003, 0.066 ± 0.002, and 0.0054 ± 0.0006, respectively. Using these values and previously published values for the rate constants for [¹¹C]DG, the average whole-brain metabolic rates for glucose in normal subjects measured with [¹⁸F]FDG and [¹¹C]DG are 5.66 ± 0.37 (n = 6) and 4.99 ± 0.23 (n = 6) mg/100 g/min, respectively. These values are not significantly different ( t = 1.56, p > 0.10) and agree well with reported values in the literature determined by means of the Kety-Schmidt technique.