The challenges and beauty of peripheral nerve regrowth
Open Access
- 28 March 2012
- journal article
- Published by Wiley in Journal of the Peripheral Nervous System
- Vol. 17 (1), 1-18
- https://doi.org/10.1111/j.1529-8027.2012.00378.x
Abstract
This review provides an overview of selected aspects of peripheral nerve regeneration and potential avenues to explore therapeutically. The overall coordinated and orchestrated pattern of recovery from peripheral nerve injury has a beauty of execution and progress that rivals all other forms of neurobiology. It involves changes at the level of the perikaryon, coordination with important peripheral glial partners, the Schwann cells, a controlled inflammatory response, and growth that overcomes surprising intrinsic roadblocks. Both regenerative axon growth and collateral sprouting encompass fascinating aspects of this story. Better understanding of peripheral nerve regeneration may also lead to enhanced central nervous system recovery.Keywords
This publication has 100 references indexed in Scilit:
- Epidemiology and predictors of spinal injury in adult major trauma patients: European cohort studyEuropean Spine Journal, 2011
- Prevalence of Diabetes among Men and Women in ChinaNew England Journal of Medicine, 2010
- Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR PathwayScience, 2008
- Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic miceNeuroscience Letters, 2008
- Impaired Axonal Regeneration by Isolectin B4-Binding Dorsal Root Ganglion NeuronsIn VitroJournal of Neuroscience, 2007
- Neuregulins: Versatile growth and differentiation factors in nervous system development and human diseaseBrain Research Reviews, 2006
- Angiogenesis at the site of neuroma formation in transected peripheral nerveJournal of Anatomy, 1997
- Neurotrophins and nerve injury in the adultPhilosophical Transactions Of The Royal Society B-Biological Sciences, 1996
- Accumulation and degranulation of mast cells in experimental neuromasNeuroscience Letters, 1994
- Responses of macrophages in rat dorsal root ganglia following peripheral nerve injuryJournal of Neurocytology, 1993