Selective rapid eye movement sleep deprivation impairs the maintenance of long‐term potentiation in the rat hippocampus
- 11 July 2006
- journal article
- Published by Wiley in European Journal of Neuroscience
- Vol. 24 (1), 243-248
- https://doi.org/10.1111/j.1460-9568.2006.04874.x
Abstract
Rapid eye movement (REM) sleep deprivation (RSD) is known to impair learning and memory. Previous studies have demonstrated that RSD induces an impairment of hippocampal long‐term potentiation (LTP). In most of these studies, RSD was set up prior to LTP induction. In this work, we focused on RSD after LTP induction. We investigated the effect of RSD for 24–48 h after induction of LTP in the dentate gyrus on LTP maintenance and whether a REM rebound after 48 h RSD affected LTP. RSD rats were deprived of REM sleep by stroking their backs using a brush, whereas control rats were allowed to sleep freely. Another control group of rats was awoken during non‐REM sleep (NRS) under the same conditions (NRS group). REM‐deprived rats displayed a faster decay of population spike amplitudes compared with the control and NRS groups over a 24‐h recording time. After 48 h RSD, there was no difference in the population spike amplitudes before or after 4 h of release from RSD. These results suggest that REM sleep after LTP induction in the dentate gyrus plays an essential role in LTP maintenance, whereas a REM rebound does not restore the RSD‐induced impairment of LTP.Keywords
This publication has 28 references indexed in Scilit:
- Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythmHippocampus, 2005
- Distinct modulatory effects of sleep on the maintenance of hippocampal and medial prefrontal cortex LTPEuropean Journal of Neuroscience, 2004
- A Novel Mechanism for the Facilitation of Theta-Induced Long-Term Potentiation by Brain-Derived Neurotrophic FactorJournal of Neuroscience, 2004
- The Nature of the Arrestin·Receptor Complex Determines the Ultimate Fate of the Internalized ReceptorOnline Journal of Public Health Informatics, 2003
- Molecular and cellular cognitive studies of the role of synaptic plasticity in memoryJournal of Neurobiology, 2002
- Evidence for a paradoxical sleep window for place learning in the Morris water mazePhysiology & Behavior, 1996
- Facilitatory but nonessential role of the muscarinic cholinergic system in the generation of long-term potentiation of population spikes in the dentate gyrus in vivoNeuropharmacology, 1994
- In vivo intrahippocampal microinfusion of carbachol and bicuculline induces theta‐like oscillations in the septally deafferented hippocampusHippocampus, 1991
- Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrusNeuroscience Letters, 1990
- Paradoxical sleep at selective times following training is necessary for learningPhysiology & Behavior, 1982