The effect of 4 dietary levels of pantothenic acid on the reproductive performance of female swine was investigated. After 4 weeks of pantothenate depletion, 32 sexually-mature gilts were divided among two replicates with 4 treatments per replicate. The total pantothenic acid intake in each treatment was 1.5, 5.9, 12.5, or 19.1 mg of pantothenic acid per kilogram of diet. A dietary intake of 1.5 or 5.9 mg was not sufficient to prevent development of pantothenate-deficiency symptoms. The deficiency affected the Durocs in replicate 1 more severely than the Hampshires and Hampshire-Yorkshire crossbreds in replicate 2. Gilts fed the 5.9 mg level conceived, and gestation was supported to term. However, abnormal pigs were farrowed. Total gestation-lactation performance, as measured by the average litter weaning weight of litters farrowed, was equal in lots receiving 12.5 and 19.1 mg of pantothenic acid per kilogram of diet and was superior to that of lots receiving 5.9 mg or less. The free pantothenic acid content of milk collected during the third and 4th week of lactation was significantly less when the gilts received only 5.9 mg of pantothenic acid as compared with higher levels of intake. Differences in the total pantothenic acid content of the milk were not significant. Under the conditions of this investigation, it appears that 12.5 mg of pantothenic acid per kilogram of diet are adequate to support normal reproduction of female swine.