A Model of Spatial Map Formation in the Hippocampus of the Rat
- 1 January 1996
- journal article
- Published by MIT Press in Neural Computation
- Vol. 8 (1), 85-93
- https://doi.org/10.1162/neco.1996.8.1.85
Abstract
Using experimental facts about long-term potentiation (LTP) and hippocampal place cells, we model how a spatial map of the environment can be created in the rat hippocampus. Sequential firing of place cells during exploration induces, in the model, a pattern of LTP between place cells that shifts the location coded by their ensemble activity away from the actual location of the animal. These shifts provide a navigational map that, in a simulation of the Morris maze, can guide the animal toward its goal. The model demonstrates how behaviorally generated modifications of synaptic strengths can be read out to affect subsequent behavior. Our results also suggest a way that navigational maps can be constructed from experimental recordings of hippocampal place cells.Keywords
This publication has 11 references indexed in Scilit:
- Reactivation of Hippocampal Ensemble Memories During SleepScience, 1994
- Dynamics of the Hippocampal Ensemble Code for SpaceScience, 1993
- Phase relationship between hippocampal place units and the EEG theta rhythmHippocampus, 1993
- Navigation by fragment fitting: A theory of hippocampal functionHippocampus, 1992
- The hippocampus as a cognitive graph (abridged version)Hippocampus, 1991
- “Dead Reckoning,” Landmark Learning, and the Sense of Direction: A Neurophysiological and Computational HypothesisJournal of Cognitive Neuroscience, 1991
- The firing of hippocampal place cells predicts the future position of freely moving ratsJournal of Neuroscience, 1989
- Neuronal Population Coding of Movement DirectionScience, 1986
- Place navigation impaired in rats with hippocampal lesionsNature, 1982
- The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving ratBrain Research, 1971