Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images
Top Cited Papers
- 1 June 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Biomedical Engineering
- Vol. 5 (6), 533-+
- https://doi.org/10.1038/s41551-021-00745-6
Abstract
Deep-learning models trained on retinal fundus images can be used to identify chronic kidney disease and type 2 diabetes and to predict the risk of the progression of these diseases. Regular screening for the early detection of common chronic diseases might benefit from the use of deep-learning approaches, particularly in resource-poor or remote settings. Here we show that deep-learning models can be used to identify chronic kidney disease and type 2 diabetes solely from fundus images or in combination with clinical metadata (age, sex, height, weight, body-mass index and blood pressure) with areas under the receiver operating characteristic curve of 0.85-0.93. The models were trained and validated with a total of 115,344 retinal fundus photographs from 57,672 patients and can also be used to predict estimated glomerulal filtration rates and blood-glucose levels, with mean absolute errors of 11.1-13.4 ml min(-1) per 1.73 m(2) and 0.65-1.1 mmol l(-1), and to stratify patients according to disease-progression risk. We evaluated the generalizability of the models for the identification of chronic kidney disease and type 2 diabetes with population-based external validation cohorts and via a prospective study with fundus images captured with smartphones, and assessed the feasibility of predicting disease progression in a longitudinal cohort.This publication has 41 references indexed in Scilit:
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